CLINICAL BIOELECTRIC MEDICINE ELECTROCEUTICAL CLASSIFICATION DEFINITIONS
Multi-facilitory Class (B)
Bio-physiological effects induced without action potentials (no repetitive depolarization and repolarization activity) all effects achieved via multiple mechanisms of action.
ANALGESIA
* Sustained Reactive Depolarization * Imitation of Hormone/Ligand Activity * Thermal Generation (Diathermy) |
* Cellular Oscillo/Torsional Response (pH normalization) * Transport of Charged Ions (D.C.) * Second Messenger Formation (cAMP) |
* Pain Mediator (Metabolite) Redistribution:
Under the influence of alternating-polarity Multifacilitory bioelectric fields, a cellular oscillo/torsional response balances metabolite concentration differences effecting pH normalization.
* Cell Membrane Repair:
Second messenger formation (CAMP) directs cell-specific activity toward membrane repair inhibiting arachidonic acid and subsequent prostaglandin (pain mediator) cascade.
* Neuron Blockade:
Application of exogenous Multifacilitory stimulus which falls within the absolute refractory period of the cell membrane inducing sustained reactive depolarization across multiple nodes of Ranvier and inhibition of axon information (pain signal) transport.
CIRCULATIORY AND LYMPHATIC INFLUENCE
* Vessel Vasoconstriction:
Higher dosage of exogenous Multifacilitory stimulus induces sustained reactive depolarization (contraction) of the vascular-wall smooth muscles - constriction of vessel.
* Vessel Vasodilatation:
Exogenous Multifacilitory stimulus induces second messenger formation (cAMP) - inhibition of smooth muscle contraction.
* Vasomotive Imitation:
Higher dosage of exogenous Multifacilitory stimulus induces vessel constriction and when combined with run/pause electroceutical application delivery - facilitates vasomotion.
ANTI-INFLAMMATORY ACTION:
Cellular oscillo/torsional response activates filtration/diffusion processes balancing metabolite concentration differences (pH normalization).
EDEMA MANAGEMENT:
Multiple mechanisms of action apply; sustained depolarization -vasoconstriction; cellular oscillo/torsional response - mediator redistribution, improved filtration and diffusion processes, enzymatic activation, cAMP formation - edematous tissue repair.
REGENERATION ACTIVATION AND SUPPORT:
Imitation of hormone/ligand activity triggers electrical conformation change in cell membrane G-protein-adenylate cyclase activation - cAMP formation - regenerative process. Membrane depolarization forces opening of voltage-gated ion channels inducing cytosolic ionic influx/efflux activity - normalized cell activity.
MUSCLE ACTIVATION AND FACILITATION
* Innervated Muscle:
Exogenous Multifacilitory stimulus above motor firing-threshold activates muscle fibers directly via sustained depolarization with minimal motor neuron involvement - repetitive repolarization (which challenges metabolism) is avoided-influence on Beta-Adrenergic receptors of the muscle cells leads to proper protein metabolic balance.
* Denervated Muscle:
Exogenous Multifacilitory stimulus at (or below) sensory-threshold dosage will favorably influence denervated muscle via cellular oscillo/torsional effect, hormone/ligand imitation and second messenger formation (cAMP). Normal metabolism is facilitated (enhanced reinnervation process.)
IMMUNE SYSTEM SUPPORT:
Rapid, alternating-polarity Multifacilitory stimulus fields facilitate charged ion movement through cell membrane gap junctions (cleansing effect) - improved intercellular communication.
FACILITATION OF METABOLISM:
Cellular oscillo/torsional response via alternating-polarity Multifacilitory stimulus fields influence the enzyme/substrate transitional state (activation energy); hormone/ligand imitation; second messenger formation; influence on voltage-gated ion channels.